StudentShare
Contact Us
Sign In / Sign Up for FREE
Search
Go to advanced search...

Mesothelioma - Research Paper Example

Cite this document
Summary
Mesothelioma Mesothelioma is a cancer of the mesothelial cells. The most commonly affected site is the mesothelial cells of the visceral and parietal pleura of the lungs. It can also occur in the mesothelial cells of the pericardium and the peritoneum, but this is quite rare (Kumar et al 2007)…
Download full paper File format: .doc, available for editing
GRAB THE BEST PAPER91.2% of users find it useful
Mesothelioma Research Paper
Read Text Preview

Extract of sample "Mesothelioma"

Download file to see previous pages

Benign mesothelioma originates from sub-mesothelial fibroblasts and is not connected to its malignant counter-part in any way. Site of origin is mostly visceral and parietal pleura and it grows in a slow fashion with no etiological relationship to asbestos. Benign mesothelioma can be treated quite effectually with surgical excision. Recurrence can be avoided if proper margins are excised. The etiology of malignant mesothelioma differs from the benign one. It has a strong co-relation with asbestos in its etiology.

Exposure to asbestos can be due to environmental exposures or occupational reasons. When asbestos is deposited in the pleura of the lungs, or if inhaled it can lead to the mesothelioma of the pleural cavities. Various forms of asbestos have been established as the cause of this cancer. These include crocidolite asbestos, amosite asbestos and anthophyllite asbestos (Bouros 2004). An estimate of 50 percent of individuals diagnosed with mesothelioma, show a positive history of asbestos exposure.

Most of these people are shipyard workers, miners or insulators. The development of asbestos in such individuals who are at great risk occurs after approximately a time period of 25 to 40 years. This points towards the genetic events that accumulate towards the development of carcinogenic mesothelial cells after asbestos exposure (Kumar et al 2007). The carcinogenic properties of asbestos have yet not been clearly understood by the medical world. Asbestos cannot be metabolized and also remains for lifetime in the lungs once inhaled.

Therefore, after inhalation or deposition of asbestos, there is a lifetime risk of mesothelioma even when the exposure has been discontinued. Asbestos causes the release of reactive oxygen species (ROS). These reactive oxygen species attack the DNA of the mesothelial cells causing damage to the DNA. Furthermore, the ROS also initiate the genetic mutations in these cells leading to cancer. Two important tumor suppressor genes undergoing mutation are p16/CDKN2A and NF2 which are always recognized in malignant mesothelioma.

Recently another factor, simian virus 40 viral DNA matter has been recognized in 80 percent of the mesothelioma cases. This highlights its strong co-relation with the occurrence of mesothelioma. The simian virus binds to the growth factor regulator genes and hence inhibits them. These include the p53 and RB genes (Kumar et al 207). Other causes which are considered as risk factors are radiation therapies, hereditary factors, immunosuppressive diseases like HIV, chronic inflammatory diseases like TB pleurisy and dietary factors (Bouros 2004).

The most characteristic clinical manifestations of malignant mesothelioma are shortness of breath (dyspnea) and chest pain. Non-specific symptoms are associated with them which include night sweats, weight loss, fatigue, malaise, fever, chills and anorexia. Along with mesothelioma findings, some individuals also present with an additional finding of pneumothorax. Other less common additional findings observed after research were, anemia, diabetic complications, empyema, metastatic disease and acute abdomen.

The prognosis of this malignancy is poor and patients die within the time duration of one year. Some patients may show an increased survival rate for up to three years and a very few patients may survive till 10 years or

...Download file to see next pages Read More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Mesothelioma Research Paper Example | Topics and Well Written Essays - 750 words”, n.d.)
Mesothelioma Research Paper Example | Topics and Well Written Essays - 750 words. Retrieved from https://studentshare.org/health-sciences-medicine/1441903-mesothelioma
(Mesothelioma Research Paper Example | Topics and Well Written Essays - 750 Words)
Mesothelioma Research Paper Example | Topics and Well Written Essays - 750 Words. https://studentshare.org/health-sciences-medicine/1441903-mesothelioma.
“Mesothelioma Research Paper Example | Topics and Well Written Essays - 750 Words”, n.d. https://studentshare.org/health-sciences-medicine/1441903-mesothelioma.
  • Cited: 0 times

CHECK THESE SAMPLES OF Mesothelioma Research Paper

Development of Post-Traumatic Stress Disorder

Research Paper Name Institution Date Part 1: Each student is to turn in a one page paper describing what they feel is the single most pressing issue in their organization or former organization that needs to be researched.... The paper will describe the problem and the purpose of the study.... hellip; (One page) Post-traumatic stress disorder (PTSD), can develop when an individual undergoes a horrifying ordeal or lives for a prolonged period of time under the threat of physical harm....
3 Pages (750 words) Research Paper

Occupational Risk Research Paper

The fibers enter the body through inhalation and lodge themselves in the pleura, the lining of the lungs, and may rest there for decades before contributing to serious health conditions, which include asbestosis, a restrictive lung disease, lung cancer, and Mesothelioma, a very aggressive form of cancer that forms in the lining of lungs and chest (Princeton University, 2012).... Most dogs will show the cancerous outcome of their exposure statistically by the time they are 8-years-old, if not younger (Mesothelioma & Asbestos Awareness Center, 2010)....
3 Pages (750 words) Research Paper

Parental Influence on Sexuality

According to an article Personality Processes and Individual Differences by Netta Weinstein and William S Ryan, it is evident that most societies hold the opinion that an… In this regard, most societies hold the opinion that individuals who grow up with autonomy-thwarting parents have lower chances of exploring their sexual values and identities and therefore disregard social aspects that Parental influence on sexuality Introduction Sexuality and sexual orientation has been an issue that is subject to both social and political debate....
2 Pages (500 words) Research Paper

Asbestos exposure from the World Trade Center disaster

The events of the 9-11 attack caused the building and debris to burn for nearly four months, leading to the release of carcinogens into the air that made it inevitable for the citizens who ended up getting infections with the deadly diseases like Mesothelioma and lung cancer.... This material was highly heat resistant, which was easy to incorporate into forming a number of materials and was relatively expensive....
5 Pages (1250 words) Research Paper

Research Paper (Accounting Research paper)

He transacts on behalf of his clients alongside maintaining his portfolio property.... Having specialized in real estate, he buys unimproved land and sale to others with an option of holding it as an… In early 2011, Al and Irene approached Tim concerning the piece of land (Moore farm) that was bought some time back at $600000....
1 Pages (250 words) Research Paper

Sufficient Evidence for the Carcinogenicity of Chromium

The paper 'Sufficient Evidence for the Carcinogenicity of Chromium' presents Chromium which is a natural metal used in a wide variety of industrial activities It is known in different oxidation states.... Elemental chromium do not occur naturally in the environment.... hellip; The author states that Chromium (III) is an essential factor for animal and human being; it has a biologically active form which facilitates the insulin interaction with his receptors sites influencing glucose, protein, and lipid metabolism....
8 Pages (2000 words) Research Paper

Improving Construction Safety and Health in the Saudi Construction Sector

This research presents a discussion about a proposed research project that will try to find new strategies for improving further construction safety and health in the nation.... Based on the premise of sustained, it is desirable to find ways and means for improving construction health and safety....
29 Pages (7250 words) Research Paper

Occupational Health Challenges in the United Kingdom

The author of the "Occupational Health Challenges in the United Kingdom" paper reviews the impacts caused by demographic, industrial structure and labor market scenarios on the occupational health (OH) challenges in the UK and its intervention programs.... nbsp;… Along with the demographic and industrial factors, labor market changes, observable in the UK working environment, can also be witnessed to impose significant influences on the OH trends in the economy....
17 Pages (4250 words) Research Paper
sponsored ads
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Contact Us